The investigation results after eight weeks of tele-Pilates and tele-yoga in females with MS showed an increase in prolactin serum levels, which may help myelin repairment; a decrease in cortisol that may be caused by adjusting HPA dysregulation; improvements in depression that may be due to reductions in cortisol serum levels, or vice versa; and the enhancement of physical activity levels, walking speed, and QoL. Here, PRL is linked to depressive symptom measurement.