LMNA and Ventricular arrhythmia: Thus, the 2020 ESC guidelines recommend an ICD implantation in patients with an LVEF between 35% and 50% and at least two risk factors, including an unexplained syncope, inducible sustained ventricular arrhythmias in programmed electrical stimulation, LGE in CMR, and pathogenic mutations in LMNA, PLN, FLNC, and RBM20 [11].