Rice et al. [34] found that insulin-dependent lactate production was significantly impaired in granulosa-lutein cells from anovulatory PCOS women, whereas Sun et al. [35] demonstrated that there are significantly increased in free fatty acids, 3-hydroxynonanoyl carnitine, and eicosapentaenoic acid in the follicular fluid samples of PCOS patients who were undergoing in-vitro fertilization (IVF). This evidence concerns the gene INS and polycystic ovary syndrome.