Classic PCOS patients have the most severe problems, with more significant luteinizing hormone (LH) elevation, more severe hyperandrogenism manifestations, insulin resistance, dyslipidemia, a higher failure rate of ovulation induction, and a lower cumulative live birth rate after IVF and intracytoplasmic sperm injection (ICSI). The gene discussed is PLOD1; the disease is polycystic ovary syndrome.