Other tumors may appear simultaneously with osteomas, such as sebaceous cysts, thyroid carcinoma, periampullary carcinoma, osteosarcoma, lipoma, liposarcoma, hepatoblastoma, adrenal adenoma and carcinoma, leiomyoma, neurofibroma, fibroma stained with anti-CD34 and anti-β-catenin, (intra-parotid) pleomorphic adenoma, locally invasive desmoid tumors, pilomatrixoma, and pigmented skin lesions; the latter can be located also intraperitoneal or retroperitoneally; the female-to-male ratio for soft tissue lesions is 3:1 [3,4,5,8,9,10,11]. The gene discussed is CD34; the disease is pilomatrixoma.