MSH2 and Lynch syndrome: In this group, every 8th woman (5% of endometrial cancer cases) has a germinal mutation in the MSH2, MLH1, MSH6 and PMS2 genes coding for DNA mismatch repair (MMR) proteins [81] (strength of evidence V) and EPCAM deletions (EPCAM-MSH2) and thus has Lynch syndrome [82] (strength of evidence IVA).