Glomerulosclerosis decreases downstream peritubular capillary blood flow, causing glomeruli in these areas to secrete excess renin; this further increases circulating angiotensin II (Ang II) levels, which then increases systemic vascular resistance and blood pressure and promotes sodium reabsorption in the proximal tubule and (via aldosterone) the collecting duct [53,54,55,56,57,58]. The gene discussed is REN; the disease is glomerulosclerosis.