Recent meta-analysis reports indicated that probiotics have a significant impact on the regulation of hormonal and inflammatory indicators, with a significant decrease in the free androgen index (FAI) and malondialdehyde (MDA), an increase in SHBG and nitric oxide (NO), and an improvement in the weight, BMI, insulin, HOMA-IR, TGs, VLDL-cholesterol, hirsutism, and total testosterone of PCOS patients [147,148,149]. The gene discussed is SHBG; the disease is Hirsutism.