Papadimitrakopoulou et al. evaluated different techniques for the detection of EGFR mutations in the ctDNA of EGFR T790M-positive NSCLC patients in the AURA3 study and found that the positive percent agreement (PPA) between droplet digital polymerase chain reaction (ddPCR) and NGS was similar and that both of these methods were more sensitive than the Cobas EGFR Mutation Test v2 (Cobas plasma) [49]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.