BRCA1 and breast carcinoma: Considering that the cumulative risk of breast cancer by age 80 is estimated to be 72% and 69% for BRCA1 and BRCA2 mutation carriers, respectively [8], the largest recent study about prophylactic mastectomy confirmed it to be an effective risk-reducing strategy for BRCA gene mutations, leaving an extremely low risk of new ipsilateral breast cancer development [18].