Several parameters were used in the univariate analysis of the Cox proportional hazards model (age, sex, histological grade, T stage, N stage, M stage, TNM stage, perineural invasion, hypertension, diabetes, smoking, drinking, recurrent status, CD3, CD4, CD8, FoxP3, and PD-L1 expression; Table 2). The gene discussed is CD4; the disease is hypertensive disorder.