After putting parameters that were significant in univariable regression (p < 0.1) in the stepwise regression and selecting predictors by AIC, independent baseline predictors of LVRR included Big ET-1 (OR 0.70, 95% CI 0.55–0.89, p = 0.003, per log increase), BMI (OR 1.07, 95% CI 1.01–1.14, p = 0.026), SBP (OR 1.02, 95% CI 1.01–1.04, p = 0.035), diagnosis of T2DM (OR 0.30, 95% CI 0.14–0.65, p = 0.002) and the treatment with ACEI/ARB (OR 2.30, 95% CI 1.02–5.21, p = 0.045). Here, EDN1 is linked to type 2 diabetes mellitus.