Normal pregnant CBA/J mice mated with BALB/c males which received transvaginal rIL-17 showed increased chances of miscarriage.Administration of rIL-17 resulted in a decrease in the production of TGF-β and IL-10 at both mRNA and protein levels (p < 0.05). Transfusion of Tregs before mating increased TGF-β and IL-10 mRNA and protein levels (p < 0.05). The gene discussed is IL10; the disease is Miscarriage.