In conclusion, using the cell culture model of in vitro hyperglycaemia and T2DM monocytes and T2DM endothelial cells and endothelial cells from gestational diabetes patients, we identified that both monocytes and endothelial cells express SGLT-2 transcripts and harbour functionally active SGLT-2 on their surface. Here, SLC5A2 is linked to gestational diabetes.