The EMPA-REG OUTCOME trial demonstrated the ability of empagliflozin to reduce cardiovascular events and overall mortality in T2DM patients with higher cardiovascular risk [1,12,15], and this by far outweighs the benefits of other glucose-lowering T2DM medications such as dipeptidyl peptidase 4 inhibitors or glucagon-like peptide-1 analogues. This evidence concerns the gene GCG and type 2 diabetes mellitus.