As shown in the results, in the gray-zone PSA (2–10 ng/mL or 2–20 ng/mL), men with medium phi (27–36) but high PRS would have a comparable risk of PCa than men with high phi (>36) but low PRS (26.7% vs. 27.4% in men with PSA 2–10 ng/mL, 31.3% vs. 34.2% in men with PSA 2–20 ng/mL). The gene discussed is KLK3; the disease is posterior cortical atrophy.