Liu et al. [25] and Zhuo et al. [26], respectively, conducted two ferroptosis-related gene signatures in glioma in 2020, in which HSPB1, CISD1, and AKR1C2 overlapped in these two models, while a prognostic predictive model specifically for low-grade gliomas was constructed [27]. This evidence concerns the gene HSPB1 and central nervous system cancer.