Patients with CKD also presented with other baseline characteristics typically associated with a worse prognosis: older age, more likely to be diagnosed with ischemic HF etiology, a higher prevalence of anaemia (probably due to CKD [20]) and higher NT-proBNP [21,22,23] albeit the fact that LVEF and functional class were similar between patients with or without CKD. The gene discussed is NPPB; the disease is chronic kidney disease.