The risk factors for middle, and long-term clinical outcomes including all-cause mortality, cardiovascular mortality, cardiovascular events, and limb amputation were CRP, serum albumin, age, DM, presence of IHD, CLTI, and vascular calcification score, including SFACS and BKACS, obtained by a univariate Cox proportional hazard analysis. This evidence concerns the gene ALB and myocardial ischemia.