EP300 and pancreatic adenocarcinoma: Human pancreatic adenocarcinoma cells grown in a collagen matrix showed enhanced acetylation of H3 histones, H3K9ac and H3K27ac, which was catalyzed by specific promoter interactions of HMGA2 causing transcriptional activation of the histone acetyltransferase (HAT) family members GCN5, p300, and PCAF [78].