In the gut, YTHDF1 recognizes the target TNF receptor associated factor 6 (TRAF6) transcript to modulate the gut immune response to bacterial infection, by the unique interaction mechanism between the P/Q/N-rich domain and host factor DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 (DDX60) death domain [20]. The gene discussed is TRAF6; the disease is bacterial infectious disease.