STAT4 and rheumatoid arthritis: Furthermore, polymorphisms in receptors downstream of cytokine signaling pathways are also associated with dysregulated inflammation, such as in the association of JAK2 polymorphisms with Behcet’s disease, TKY2 polymorphisms with Crohn’s, systemic lupus erythematosus (SLE), STAT3 with psoriasis, STAT4 with rheumatoid arthritis (RA), and STAT6 with atopy and asthma [22,23,24,25,26,27].