Furthermore, type 2 cytokines are a major regulator of mucin gene expression in an in vivo model [115] and, more importantly, as IL-4 and IL-13 facilitated MUC2 and MUC5AC transcription by activating either the STAT6 or NF-κB pathways with ovalbumin (OVA) in the asthma model [116,117]. This evidence concerns the gene MUC5AC and asthma.