MUC5AC and neoplasm: M et al. found that the downregulation of mucin synthesis was lower, as was as the amount of the glycosylated residuals in Kras-mutant mice induced by a high-fat diet [137], which in turn caused susceptibility to inflammatory disease, increased tumor risk, and pathogens [138]; all of these can be reversed by capsaicin by involving TRPV1 to restore the gut barrier [42].