Although the MLL-AF9 harboring THP-1 and mAF9 cells showed limited sensitivity to Vidofludimus, recent reports suggest that second-generation DHODH inhibitors may have a particular role to play in MLL-AF9 AML and are now available at low concentrations (74 nM) with low toxicity [35]. Here, MLLT3 is linked to acute myeloid leukemia.