The objectives of the present experiments sought to investigate if maintenance of increased levels of endogenous APOA4 in APOA4-Tg mice could enhance BAT thermogenesis after short-term intake of HFD for 4 weeks or long-term feeding of HFD for 10 weeks, and lead to attenuated body weight gain and plasma lipids and thus protection against HFD-induced obesity. Here, APOA4 is linked to Obesity.