METTL3 and hepatocellular carcinoma: METTL3 sensitized HCC cells to sorafenib by stabilizing forkhead box class O3 (FOXO3) in an m6A-dependent manner, thereby inhibiting the transcription of autophagy-related genes, including ATG3, ATG5, ATG7, ATG12, and ATG16L1 (Figure 3C) [19].