Targeting METTL1 or WDR4 led to the decreased expression of m7G-modified tRNAs and reduced the translation of the oncogenes and negative regulators of autophagy in an m7G-related codon-dependent manner, which induced mammalian target of rapamycin complex C1 (MTORC1)-mediated autophagy via the dephosphorylation of Unc-51-like kinase 1 (ULK1) and cell death in ESCC [157]. The gene discussed is METTL1; the disease is esophageal squamous cell carcinoma.