DEPDC5 (DEP domain containing 5), NPRL2 (nitrogen permease regulator-like 2), and NPRL3 (nitrogen permease regulator-like 3) are 3 components of the GATOR1 (GTPase-activating protein (GAP) activity toward Rags 1) protein complex, and their loss-of-function mutations have been identified in MCD-associated epilepsies [92,93,94]. Here, DEPDC5 is linked to epilepsy.