The top 10 drugs have been reported in previous studies, namely Celastrol [21], LDN-193189 [22], XPNPEP1 [23], GNB5 [24], Importazole [25], LDHB [26], NUAK1 [27], IFNG [28], IFNB1 [29], and YWHAH [30], suggesting that these drugs may be effective candidate drugs for the treatment of fluorosis (Table 2). This evidence concerns the gene XPNPEP1 and dental fluorosis.