MYC and glioblastoma: Taking into account that the metabolic control of Myc expression in GBM and in other cancer types is largely similar [241,242,243,244,245,246], one of the best recognized and characterized metabolic pathways regulating Myc in GBM is glycolysis, which exerts its modulatory role on Myc expression especially through the mTORC2 component of the mTOR complex [275].