EGFR and glioblastoma: Indeed, genes that are typically mutated in GBM, such as phosphatase and TENsin homolog deleted on chromosome 10 (PTEN), epidermal growth factor receptor (EGFR), isocitrate dehydrogenase (IDH1), p53, and v-raf murine sarcoma viral oncogene homolog B1 (BRAF), drive downstream metabolic pathways divergent from those found in healthy cells and are strictly dependent on the TME.