Binding of the Myc/Max and AHR/aryl hydrocarbon receptor nuclear translocator (ARNT) heterodimers on the promoter regions of CAD, DHODH, UMPS, and LDHA has been postulated [286], and in vivo lactate labeling overlaps Myc expression in patient-derived GBM samples [287]. The gene discussed is MAX; the disease is glioblastoma.