MYC and glioblastoma: Here, based on the available literature to date, we provide a comprehensive view of Myc-dependent control of GBM gene expression profiles and metabolism, highlighting Myc’s role as pivotal regulator of GBM metabolic genes, as well as a target of GBM cell metabolic pathways, in a bidirectional fashion that places Myc at the intersection between transcriptional output and metabolism in glioblastoma.