Indeed, genes that are typically mutated in GBM, such as phosphatase and TENsin homolog deleted on chromosome 10 (PTEN), epidermal growth factor receptor (EGFR), isocitrate dehydrogenase (IDH1), p53, and v-raf murine sarcoma viral oncogene homolog B1 (BRAF), drive downstream metabolic pathways divergent from those found in healthy cells and are strictly dependent on the TME. Here, IDH3A is linked to glioblastoma.