Given the infiltrative nature of GBM, surgical eradication of GSCs is always incomplete; further, a number of efficient mechanisms, including DNA repair systems, as well as the Notch, NF-κB, EZH2, and PARP pathways [89,93,94,95], are engaged by these cells when exposed to radiation and chemotherapeutic agents, escaping apoptosis [96]. This evidence concerns the gene NFKB1 and glioblastoma.