Related to that, in a genome-wide association study investigating the transcriptional activities and DNA binding of SOX4 and RELA/p65, SOX4 and RELA were found to physically interact with each other on the chromatin and orchestrate several processes to regulate the expression of the downstream genes of TNF and then enhance the transformation of FLSs in arthritis [10]. This evidence concerns the gene SOX4 and Arthritis.