However, according to both the preclinical and the clinical studies, the progression of arthritis diseases was found to be associated with dysregulated levels of SOX4 and SOX11 TFs (summarized in Table 1 and Table 2), which indicates that both could be used as diagnostic biomarkers of arthritis; however, there is still little data available regarding the role of SOX11 in RA. The gene discussed is SOX4; the disease is Arthritis.