PTGER3 and cardiovascular disorder: The rs2241360 polymorphism in PTGER1 and the rs7533733 variant in PTGER3 have been associated with risk of nephrosclerosis and consequent cardiovascular diseases; specifically, the T allele of rs2241360 (PTGER1) is protective against nephrosclerosis and CVD, while the GG genotype of rs7533733 (PTGER3) increases the risk and lowers the survival of carriers [233].