In particular, EP1 has been associated with hypertension and cardiac fibrosis; EP2 with vasodilatation, stimulation of inflammation, and cardiac hypertrophy; EP3 with pro-inflammatory responses, atherothrombosis, hypertension, and cardiac dysfunction; and EP4 with vasodilatation, inflammation, cardiac protection, and atherosclerosis [144,145,147]. This evidence concerns the gene PTGER4 and hypertensive disorder.