PTGES and myocardial ischemia: Deletion of mPGES-1 during acute cardiac ischemia increases the infarct size and promotes myocardial ischemia/reperfusion injury; moreover, the mPGES1/PGE2/EP4 axis limits the interaction between leukocytes and endothelial cells of coronary arteries in the context of I/R injury, protecting the heart and preserving microcirculation during the reperfusion phase [194].