NLRP3 and chronic kidney disease: Experimental models and clinical studies have demonstrated that the NLRP3 inflammasome mediates several mechanisms of CKD onset and progression, sustaining the sterile renal chronic inflammation observed in CKD through the regulation of proinflammatory cytokines, promoting tubule-interstitial injury, glomerular diseases, renal inflammation and fibrosis pathways [12,13,14,15,16].