More interestingly, Sahay et al. reported that TGF-β-1 levels as well as MMP9 were increased in the tears in AH in patients with PXF and PXG as compared to POAG, suggesting that the elevated TGF-β-1 levels may affect ECM remodeling mechanisms [56]. The gene discussed is TGFB1; the disease is open-angle glaucoma.