In a multicentric longitudinal study carried out in a cohort of 3624 consecutive SLE patients, a 10-year probability-predictive nomogram for the development of PAH, including clinical variables and three autoantibodies (anti-RNP, anti-SSA and anti-SSB) was developed, confirming the close association between the anti-RNP antibodies and PAH in SLE [102]. This evidence concerns the gene RNPC3 and pulmonary arterial hypertension.