NPPB and systemic sclerosis: Both BNP and NT-proBNP can be used in the risk stratification of PAH patients according to the most recent guidelines [1]; in SSc-PAH, both peptides correlate with mPAP [162], while the NT-proBNP levels also showed a correlation with the PVR value, right atrial pressure and cardiac index in SSc-PAH [163].