A more robust and recent study comprising 675 patients with SSc found that hs-cTnT was associated with an increased risk of death and PAH in the univariate analysis, although it did not add relevant information when it was integrated into models with clinically relevant variables (possibly due to the small number of patients who developed PAH, n = 39) [174]. The gene discussed is TNNT2; the disease is pulmonary arterial hypertension.