When human epidermal growth factor (EGF) binds to EGFR, EGFR and its relatives, the ERBB family members, have mutations or increased expression, which will trigger a cascade reaction of upstream and downstream signaling pathways in the ERBB signaling pathway, especially the intracellular tyrosine kinase signaling pathway, eventually becoming various malignant tumors [105]. Here, EGFR is linked to cancer.