Moreover, as this highly diverse bioactive peptide has roles in neurogenesis/differentiation, embryonic development, and neuronal repair, and therein brain development, these results reinforce the importance of continued research into not only fundamental research into signaling mechanisms downstream of PACAP, but also gaining hints from the omics data to provide therapeutic possibilities for brain pathologies [72], including stroke, one of the first reasons our group has been researching PACAP38 [11]. This evidence concerns the gene ADCYAP1 and stroke disorder.