We have been studying PACAP38 role in neuroprotection, in particular, cerebral ischemia, using a mouse model of permanent middle cerebral artery occlusion (PMCAO) that resulted in the identification of a collapsing response mediator protein 2 (CRMP2) from the ischemic brain tissue post-intraventricular administration of PACAP38 [9,10] and numerous gene candidates by establishing a genome-wide approach [11]. Here, ADCYAP1 is linked to brain ischemia.