We have further identified several proteins in saliva, including AMY1B, AMY2B, BPIB2, CPPED, DEF3, H2A2A, H2BC18, ISK7, LEG1H, PNP, PRELP, SPB13, STAT, QSOX1, RNF150 and VPS41, and in serum, namely, CEP290, CO8B, CO6, CPN2, GPKOW, HEP2 and PIPOX which have not been reported in the literature to previously be associated with breast cancer. The gene discussed is PIPOX; the disease is breast cancer.