TCam-2 has elevated H3K4me3 and H3K27ac for SOX17 and low H3K4me3 and H3K27ac for SOX2 whereas NCCIT, an EC cell line derived from a mediastinal germ cell tumor, has elevated H3K4me3 and H3K27ac for SOX2 and low H3K4me2 and H3K27ac for SOX17 [96,97]. This evidence concerns the gene SOX2 and germ cell tumor.