Various intracellular signaling pathways (signal transducer and activator of transcription 3/nuclear factor of activated T-cells, miRNA) and several growth factors, vasoconstrictors or cytokines involved in PAH including PDGF, BMPR2 or interleukin-17 have been found to modulate KNCK3 channel expression and activity [17,64,65,66]. This evidence concerns the gene BMPR2 and pulmonary arterial hypertension.