Several clinical observations have indicated that different agents (e.g., herbs, food, environments) have the ability to influence migraine headaches via the modulation of subclasses of TRP superfamilies (TRP-ankyrin 1—TRPA-1; TRP-vanilloid 1—TRPV-1; TRP-melastatin 8—TRPM-8) [13,19]. The gene discussed is TRPA1; the disease is Headache.