TNF and rheumatoid arthritis: So far, several single nucleotide polymorphisms (SNPs) in different known loci such as NUBPL (rs2378945), NCTN5 (rs1813443), PLA2G4A (rs12142623 and rs4651370) [21], LINC02549 (rs7767069), LARRC55 (rs717117G) [22], MED15 (rs113878252), MAFB (rs6065221) [23], CD84 (rs6427528 and rs1503860) [24], TNF (rs1800629), EYA4 (rs17301249) [25], PDZD2 (rs1532269) [26], and CCL21 (rs2812378) [27] genes or in unknown loci, including rs4411591, rs7767069, rs1447722, and rs1568885 [21], have been identified, which are associated with a response to anti-TNF treatments in RA.