Nonetheless, drug-induced neutropenia not always means interference with neutrophil-mediated antimicrobial host defense, as reported, for example, for IL-6 inhibitors and Janus Kinase (JAK) inhibitors [123,124], where neutropenia could serve as an indicator of efficacy without necessarily mirroring an increased rate of infections [125]. This evidence concerns the gene IL6 and Decreased total neutrophil count.