TLR4 and psoriasis: They act as key players in inducing and maintaining inflammation in different manners: (i) DNA-LL37 complexes stimulate the production of Interferon-alpha (IFN-α) and IFN-β by plasmacytoid dendritic cells (pDCs) [97], whereas (ii) RNA-LL37 complexes stimulate TNF-α and IL-6 production by myeloid DCs [98,99], (iii) NETs signaling, through activation of Toll-Like Receptor-4 (TLR-4) and IL-36, amplifies skin inflammation [94] and (iv) IL-17A, a central cytokine in psoriasis pathogenesis, is released by neutrophils during the formation of NETs in psoriatic lesions [100].