In a preliminary study, circulating resistin levels were found to be similar between SSc and controls and, when patients were classified into two groups (i.e., patients with high or normal resistin levels on the bases of healthy control levels), no difference between these two groups was demonstrated for the frequency of cutaneous vascular manifestations, including pitting scars, telangiectasia, and nailfold bleeding [215]. This evidence concerns the gene RETN and Telangiectasia.