Among class I and II helical cytokines, serum from SSc patients was reported to be characterized by considerably higher values of IL13, IL4, IL10 [142,143], IL6 (which positively correlated with both PAH and cardiac involvement) [144,145], IL22 [146], and IL35 [147,148], which was particularly increased in patients with an early NVC pattern [148]. This evidence concerns the gene IL13 and systemic sclerosis.