JAM3 and systemic sclerosis: Among these cell-to-cell adhesion molecules, JAM-A (also known as JAM-1/F11 receptor) and JAM-C (JAM-3), which have been both demonstrated to behave as pro-angiogenic molecules, represent the most investigated JAMs in SSc, with their extracellular domains being cleaved and released as soluble forms by a disintegrin and metalloproteinases (ADAMs) in inflammatory conditions [34,35,37,38].