In this meta-analysis, involving many of the aforementioned studies [244,245,246,247,248,251,252,253], the pooled sensitivity and specificity of NT-proBNP to diagnose SSc-PAH were found to be 0.84 and 0.68, respectively, revealing that NT-proBNP has certain diagnostic value for PAH due to its better specificity and moderate sensitivity. This evidence concerns the gene NPPB and systemic sclerosis.