The GRp78 inhibitor 13 suppressed KRAS expression and revealed antiproliferative and pro-apoptotic activities in various KRAS-mutant cancer cell lines (A427 lung adenocarcinoma, H460 non-small cell lung carcinoma, HCT-116 and LS180 colon carcinomas, PANC-1 and CFPAC-1 pancreatic ductal adenocarcinomas), and induced apoptosis in A427, HCT-116, and PANC-1 cells by caspase activation [73]. The gene discussed is HSPA5; the disease is cancer.