Inhibition of Hsp70-Bag3, suppression of FoxM1 and HIF1α pathways, in vivo inhibition of MCF-7 tumor growth, induction of p21, suppression of FoxM1 and surviving, sensitization of glioma to (−)-gossypol (AT-101) and ABT-737, suppression of Mcl-1, synergistic antiproliferative effects with doxorubicin [41,42,43]. The gene discussed is HSPA1A; the disease is central nervous system cancer.