TP53 and neoplasm: Compound 9a showed antiproliferative activities against various osteosarcoma, breast, and pancreatic carcinoma cell lines at IC50 values of 5–10 μM independent of the p53-state of the tumor cells, induced cell death independent of caspase activation, and led to dysfunctional autophagy by the formation of p62-oligomers/aggregates [59].