The benzofuran derivative 19 (Figure 3, FL5) is a strong binder and stabilizer of Grp78 (Tm increase > 2 °C), which was associated with its anticancer and antiangiogenic activities against renal cell carcinoma (RCC) cells (10 μM of 19 led to 50% cell death) and HUVECs (EC50 = 1.5 μM), while it was inactive against mouse fibroblasts [81]. The gene discussed is HSPA5; the disease is renal cell carcinoma.