HSPA1A and colon carcinoma: In 2009, the adenosine-derivative 1 (Figure 1, VER-155008) was identified as a selective NBD-targeting Hsc70/Hsp70 inhibitor (IC50 = 0.5 μM), which showed antiproliferative effects on HCT-116 colon carcinoma cells (GI50 = 5.0 μM), reduced Raf-1 and Her2 protein levels, and enhanced the apoptosis induction by the Hsp90 inhibitors 17-AAG and VER-82160 in HCT-116 cells [19,20].