The Hsp40 protein DNAJA1 was upregulated in colorectal cancer cells, but treatment with compound 28 strongly inhibited the level of the Hsp40 protein DNAJA1 in SW480 (IC50 = 24.7 μM), RKO (IC50 = 25.5 μM), LOVO (IC50 = 56.0 μM) and SW620 cells (IC50 = 48.3 μM), while no effects on Hsp70 and Hsp90 were found [120]. This evidence concerns the gene DNAJB1 and colorectal cancer.