Compounds 30a and 30b revealed antiproliferative activities against HN31 pharyngeal squamous cell carcinoma cells (IC50 = 1.2 μM for 30a and 0.6 μM for 30b) and suppressed DNAJA1 and conformational mutant p53 levels in HN31 cells, accompanied by suppression of tumor cell migration based on downregulation of active Cdc42 and Rac. The gene discussed is AKT1; the disease is neoplasm.