TP53 and familial pancreatic carcinoma: In addition, compound 33 suppressed mutant p53 in SU 86.86 (G245S), BXPC-3 (Y220C), and Pan 10.05 (I255N) pancreatic cancer cells, while mutant p53 levels in MIA-PaCa-2 (R248W) and PANC-1 (R273H) were not affected by compound 33.