Consistent with our hypothesis that AD-associated mutant (F113L) or (F131L) TOMM40 cause neurotoxicity and increase AD risk by inducing microglial activation, Taiwanese AD patients carrying TOMM40 missense (F113L) or (F131L) variants exhibit an increased plasma level of IL-6, IL-18, IL-33, and COX-2. This evidence concerns the gene IL6 and Alzheimer disease.