Regarding the clinical relevance of differentially expressed transcripts in DIS3-mutated cases, five lncRNAs (AC015982.2, AL353807.2, AC013400.1, ASH1L-AS1, and AL445228.3) are associated with a shorter OS, two of which (AC015982.2 and AL445228.3) are also independent predictors of PFS, although future studies are required to determine the pathological roles of these lncRNAs in MM [54]. The gene discussed is DIS3; the disease is Miyoshi myopathy.