CFTR and cystic fibrosis: These advances included a more complete understanding of the importance of adequate salt/water and nutrition replacement, the evolution of multiple airway clearance and antibiotic treatment strategies, and most recently, the innovative development of specific interventions to improve the functioning of the abnormal CF transmembrane conductance regulator (CFTR) protein, which is at the core of the CF phenotype [5,6,7,8,9].