CTSS and colonic neoplasm: Furthermore, incubation of colon cancer cells with MM131—another pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamide—induced apoptosis of DLD-1 and HT-29 cells with observed down-regulation of mTOR kinase, soluble intercellular adhesion molecule-1 (sICAM-1), and cathepsin, together with up-regulation of beclin-1 B [33].