The ApcMin/+ CB2−/− mice exhibited a similar immunosuppressive profile, with upregulation of CD11b+, M-MDSCs, and PMN-MDSCs (Figure 6A), although in contrast to the AOM/DSS model, dendritic cells (DCs) were also upregulated, while anti-tumor eosinophils and CD8+ T cells were downregulated (Figure 6A). Here, CNR2 is linked to infectious otitis media.