Like the AOM/DSS model, cancer development in the CB2-deficient Apc+/Min mice appeared more aggressive (Figure 4), with shorter colons (Figure 4D) and an increased number of adenomas in the small and large intestine (SI and LI, respectively, Figure 4B,C) seen in the ApcMin/+CB2−/− mice. This evidence concerns the gene CNR2 and infectious otitis media.