The observation that IL-6 is strongly upregulated in the inflammatory environment of ApcMin/+ mice [48,49] and colon cancer patients in males and females [50,51,52] may therefore explain the lack of sex-related differences detected in the influence of CB2 on colon cancer severity in our ApcMin/+ model (Figure 4). This evidence concerns the gene CNR2 and malignant colon neoplasm.