Some series report that the overall frequency of HRR mutations in NSCLC is about 14.2%, the most common mutated genes being ATM, BRCA2, AT-rich interactive domain-containing protein (ARID) 1, CHEK2, BRCA1, ATR, RAD50, MSI, and also high TMB. This evidence concerns the gene BRCA1 and non-small cell lung carcinoma.