GPER1 and early-onset autosomal dominant Alzheimer disease: Similarly, GPER1 activation inhibited oxidative stress, neuroinflammation, and apoptosis, improving memory and cognitive dysfunctions in a mouse model of Alzheimer’s disease (5XFAD), a mouse model of vascular dementia, and a mouse model of 3,5-dihydroxyphenylglycine (DHPG)-induced long-term depression (LTD) [68,72,112].