Proband 579P1 also had a family history of cancer, including BC (2 cases), prostate cancer (2 cases), oral cancer (one case), and colon cancer (one case); this patient presented a molecular profiling of positive for estrogen and progesterone receptor with bilateral infiltrating ductal carcinoma and with negative lymph nodes, diagnosed at 56 years of age. The gene discussed is PGR; the disease is malignant colon neoplasm.