BRCA1 and neoplasm: Further, this mutation was found in 3.39% of BRCA1/2-negative familial BC cases (OR = 2.11, 95% CI = 1.34–3.32, p = 0.001) with an even higher carrier frequency of 5.88% (12 in 204) observed in a subgroup of mainly unselected cases with a triple-negative BC tumor phenotype (OR = 3.56, 95% CI = 1.81–6.98, p = 0.01) [15].