Proband F188P1 is a patient belonging to a family with BC (3 cases), lung cancer (1 case), testicular cancer (2 cases with very early diagnosis), colon cancer (one case), and melanoma (one case); this patient was diagnosed with early onset of BC (34 years old) and positive for estrogen and progesterone receptors with negative lymph nodes. The gene discussed is PGR; the disease is breast cancer.