Proband F188P1 is a patient belonging to a family with BC (3 cases), lung cancer (1 case), testicular cancer (2 cases with very early diagnosis), colon cancer (one case), and melanoma (one case); this patient was diagnosed with early onset of BC (34 years old) and positive for estrogen and progesterone receptors with negative lymph nodes. This evidence concerns the gene PGR and melanoma.